Design with the manufacturing process in mind, not just form or prototype; prototype-friendly features (complex undercuts, sharp internal corners, deep thin walls) may be hard or expensive in production molds.
Plan for mold features: gates, ejection pins, parting lines, cooling. Their placement will affect aesthetics, part strength, tolerances, surface finish, cost.
Consider material behavior: shrinkage, warpage, cooling rates. Designs should accommodate these (wall thickness uniformity, ribs, draft angles).
Use mold flow or simulation early especially when going to multi-cavity molds, or when there are complex geometries.
Iterate between toolmaker, mold designer, and product designer so you catch manufacturability issues early.
Scaling up a mold (more cavities, higher volume) is not just multiplying cost, the complexity grows nonlinearly (balance of flow, heat, ejector system, etc).